Filtration of pharmaceutical ingredients

(Chemical synthesis)

1 - Separation

The chemical reactor is followed by the first separation phase. Solids, such as the catalyst bound to activated carbon, or other reaction byproducts are filtered out first. In addition to bag filtration, sheet or stacked disc cartridge filtration is particularly suitable. In many cases, the combination of BECO standard or BECOPAD depth filter sheets made of cellulose, in an enclosed frame filter, such as the BECO INTEGRA PLATE is the optimal solution for solids separation. If the requirements for chemical compatibility with regard to raw materials or sealing materials are higher, stacked disc cartridge filtration is recommended. A system consisting of BECODISC stacked disc cartridges and the enclosed BECO INTEGRA DISC stacked disc cartridge housing is a clean solution in this case. Optionally, the system can also be equipped with stacked disc cartridges with increased cell spacing.

2- Clarifying filtration

Following the solids separation, clarifying filtration takes place for the separation of fine particles. Depending on the desired purity of the filtrate, this step is carried out in several stages using a combination of stacked disc cartridge and cartridge filtration to protect downstream components.

3 - Crystallization

Active pharmaceutical ingredients are processed in the drug either in powder or in liquid form. There are therefore two alternative process routes.

In liquid form, the active pharmaceutical ingredients undergo various filtration steps after crystallization. BECOPAD depth filter sheets are ideal for the separation of fine particles and colloids, for the reduction and separation of microorganisms and for the protection of a final membrane filtration. The use of BECODISC BC activated carbon stacked disc cartridges with BECO CARBON depth filter sheets is recommended for the separation of undesirable organic by-products or decolorization.

Single-sheet filters such as the BECO INTEGRA SOLO are used in solids extraction after crystallization.

4 - Filling and Drying

A further, final filtration stage is carried out to protect the tank or container filling. Depending on the requirements, the liquid active ingredients are filtered using filter bags or filter cartridges.

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